PBS-80 Vertical-Wheel Bioreactor
Unlock large-scale manufacturing of your cell therapy products.
The PBS-80 Vertical Wheel bioreactor is the ultimate tool for large-scale manufacturing of therapeutic cells. With the currently largest available working volume of 80L, the PBS-80 can handle commercial manufacturing of cell therapy products.Request Quote
- Expand clinical stage production or scale up into commercial scale manufacturing
- Touchscreen interface for intuitive process customization, control, and reporting
- Adjustable height harvest valve (AHHV) allows for rapid medium exchange, sampling, and harvesting
- Configurations available for use with single-use or reusable DO and pH sensors
- Installation and operations qualification protocols available for sale
Vertical-Wheel bioreactors provide the optimal hydrodynamic mixing environment for anchorage-dependent human cells that require suspension as large particles, such as cell aggregates or cells grown on microcarriers.
The floored version has more panels around the circumference of the Vertical-Wheel that create cup-like sections and is better suited for cells grown on microcarriers or as single cells. The floorless version is nearly identical but with less panels and allows more fluid flow towards the axle, and is better suited for cell aggregate applications. Both versions have nearly identical hydrodynamic performance.
The 3L, 15L, and 80L bioreactors are available in one version that accommodates single-use sensors and another version that is designed for reusable sensors (no cross-compatibility). The housing for the reusable sensor version can be modified to solely accommodate single-use sensors; please contact our Applications Engineering team for the service details.
The AHHV extends from the bioreactor housing through the bottom of the single-use vessel using a sterile connection. Similar to a periscope, the tip of the AHHV can extend just beyond the top of a bed of settled cells to drain spent liquid with minimal supernatant for a medium exchange process, or can be used to harvest cells suspended in media. The AHHV is only available in 15L and larger bioreactors. More details can be found in respective User Manuals.
The 3L bioreactor’s software allows for customizable programming of process controls and real-time monitoring of parameters using various sensors. Feedback loops can be used to pause a run based on deviations from a set range.
Yes, the software on 3L and larger size bioreactors allows for remote process monitoring, adjustments, and alarm reporting over a secure connection to various devices.
The software can customize how often and what kind of data will be stored on the bioreactor’s on-board hard drive. Automatic downloading of data can be directed to a local computer with direct LAN connection. All user logins, process changes, and data histories follow 21 CFR Part 11 requirements for cGMP.
Please use the Contact form to describe your process requirements and our Applications Engineering team will be able to assist with your planning.
Please use the Contact form to reach out to our Applications Engineering team with any inquiries.
The 80L bioreactor is intended to be placed on the floor and has wheels for movement. Technical specifications such as dimensions and weight are available on the 80L product page.
All components of PBS bioreactors (housing, vessels, and software) have been designed to be intuitive and easy to use even for those with no previous experience using bioreactors. The provided User Manual provides detailed instructions for common use cases and you can also Contact Us with any other questions.
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