PBS-80 Vertical-Wheel Bioreactor

Recommended for working cell culture volumes ranging from 40-80L

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The Go-to Choice for Cell Therapy Commercial-scale Production

The PBS 80 Vertical Wheel Bioreactor sets the benchmark for large scale therapeutic cell manufacturing. Engineered for working volumes between 40 L and 80 L, it delivers the reliability, control, and scalability needed for commercial scale production of cell therapy products.

Key Advantages for Your Cell Therapy

  • Reliable: Seamlessly scale from clinical trials to full commercial manufacturing with consistent mixing dynamics and proven scalability
  • Configurable: The Adjustable Height Harvest Valve (AHHV) enables rapid, sterile medium exchange, sampling, and harvest
  • GMP Compliant: A touchscreen interface offers intuitive process customization, automation, and detailed reporting for GMP aligned operations

PBS-80 Bioreactors vs. Stirred Tank Bioreactors

Feature Vertical-Wheel Bioreactor Stirred Tank Bioreactor
Mixing Mechanism Vertical impeller that generates a gentle, large-scale, upward-and-outward flow. Horizontal impeller that creates high-shear zones and turbulent eddies.
Shear Stress Very low. Designed to minimize hydrodynamic stress, making it ideal for shear-sensitive cells like stem cells and cell aggregates. High, especially near the impeller blades. Can be detrimental to fragile cells, although impeller designs have been optimized to reduce this.
Scalability Linear. The hydrodynamic conditions remain consistent as the volume increases, allowing for predictable scale-up. Complex. Scaling up requires careful optimization to maintain consistent conditions, as fluid dynamics change with volume.
Homogeneity Excellent. The vertical wheel creates a highly uniform environment with eliminating occurrences of high turbulence. Good. Requires careful design to ensure uniform mixing and prevent gradients, especially in large vessels.
Applications Primary: Shear-sensitive cell cultures (hiPSCs, MSCs, T-cells), viral vectors, and exosomes Primary: Large-scale fermentation (bacteria, yeast), and general mammalian cell culture (e.g., CHO cells for biologics).

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Single-use bioreactor company of the year 2025

Product Parts and Technical Specifications

Part Numbers
Specifications
Product Resources
Product Type Product Name Product Number  
Bioreactors PBS-80 Vertical-Wheel Bioreactor (120 V) IA-80-B-511 Request a quote
PBS-80 Vertical-Wheel Bioreactor (240 V) IA-80-B-512 Request a quote
Single-Use Vessels PBS-80 Vertical-Wheel Single-Use Vessel (Floored Wheel) [Legacy Product] IA-80-D-504-L Request a quote
PBS-80 Vertical-Wheel Single-Use Vessel (Floored Wheel) IA-80-D-511-L Request a quote
Accessories PBS Autoclavable Probe Connector IA-UNI-DA-001 Request a quote
Reusable DO Sensor, 12mm OD x 220mm L with Right-Angle IC00468 Request a quote
Reusable pH Sensor, 12mm OD x 225mm L IC00469 Request a quote
Software PBS-80 Vertical-Wheel Bioreactor Software 3.0 (21 CFR Part 11 cGMP Upgrade) IA-80-SW-001 Request a quote
Working volume range: 45 – 80 L
Gas control Mass flow controllers for air, N2, O2, CO2/td>
Vessel Construction Polyvinylidene Fluoride (PVDF)
Product contact materials Meet requirements for USP Class VI Testing for Plastics <88> and/or ISO 10993
Download Full  Technical Spec Sheet

Vertical-Wheel Bioreactor
Scaling Calculator

Vertical-Wheel Bioreactor
Support Portal

Vertical-Wheel Bioreactor
Product Guides and Manuals

Single-use bioreactor company of the year 2025

The PBS Mini Bioreactor 90 Day Guarantee

If you are not satisfied with the performance of the PBS-Mini products or accessories get your money back.  Must show necessary performance documentation to qualify.