PBS-3 Vertical-Wheel Bioreactor
The new standard of single-use bioreactor for cell therapy applications
The PBS-3 Vertical-Wheel bioreactor is designed to take your cell culture process to the next level. Process development and optimization started in PBS-Minis can be scaled up into this self-contained bioreactor with customizable control of process parameters.Request Quote
- Single-use vessels and software qualified for use in clinical trials, including first-in-human studies
- Touchscreen interface for intuitive process customization, control, and reporting
- Configurations available for use with single-use or reusable DO and pH sensors
- Installation and operations qualification protocols available for sale
Successful transition of a small scale cell culture process designed in PBS Minis into the 3L bioreactor represents the first step in achieving true scalability of manufacturing therapeutic cells. The 3L can meet production needs for early stage clinical studies and also serves as stepping stone for continued scale up into the 15L bioreactor.
The floored version has more panels around the circumference of the Vertical-Wheel that create cup-like sections and is better suited for cells grown on microcarriers or as single cells. The floorless version is nearly identical but with less panels and allows more fluid flow towards the axle, and is better suited for cell aggregate applications. Both versions have nearly identical hydrodynamic performance.
The 3L, 15L, and 80L bioreactors are available in one version that accommodates single-use sensors and another version that is designed for reusable sensors (no cross-compatibility). The housing for the reusable sensor version can be modified to solely accommodate single-use sensors; please contact our Applications Engineering team for the service details.
For Mini vessels, the cap on top can be unscrewed for pipetting in a biosafety hood. For the 3L bioreactor, media can be withdrawn from a sample line connected to the vessel via an automated pump or manually. For the 15L and 80L bioreactors, the adjustable height harvest valve can fulfill both functions.
The 3L bioreactor’s software allows for customizable programming of process controls and real-time monitoring of parameters using various sensors. Feedback loops can be used to pause a run based on deviations from a set range.
Yes, the software on 3L and larger size bioreactors allows for remote process monitoring, adjustments, and alarm reporting over a secure connection to various devices.
The software can customize how often and what kind of data will be stored on the bioreactor’s on-board hard drive. Automatic downloading of data can be directed to a local computer with direct LAN connection. All user logins, process changes, and data histories follow 21 CFR Part 11 requirements for cGMP.
Yes, the 3L bioreactor is designed to be place on a lab bench, rolling cart, or similar platform. Technical specifications such as dimensions and weight are available on the 3L product page.
Please use the Contact form to describe your process requirements and our Applications Engineering team will be able to assist with your planning.
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