PBS-0.5 Mini Vertical-Wheel Bioreactor

Recommended for working cell culture volumes ranging from 300-500mL

The Best Choice for Your Early Stage Cell Therapy Optimization

The PBS 0.5 Mini single use bioreactor supports 300 mL–500 mL working volumes, offering an ideal platform for early stage cell therapy optimization. Its vertical-wheel mixing technology ensures homogeneous conditions and smooth scale up to larger systems.

Key Advantages for Your Cell Therapy

Sterile handling: Removable vessel caps allow straightforward aseptic liquid transfer in a biosafety cabinet.
Clinical readiness: All product-contact materials comply with regulatory standards for use in first-in-human clinical trials.
Flexible platform: A universal base unit supports PBS-0.1, PBS-0.5, and PBS-0.5 Mini Perfusion single-use vessels, enabling smooth process scalability.

PBS-05 Mini Bioreactors vs. Stirred Tank Bioreactors

Feature	Vertical-Wheel Bioreactor	Stirred Tank Bioreactor
Mixing Mechanism	Vertical impeller that generates a gentle, large-scale, upward-and-outward flow.	Horizontal impeller that creates high-shear zones and turbulent eddies.
Shear Stress	Very low. Designed to minimize hydrodynamic stress, making it ideal for shear-sensitive cells like stem cells and cell aggregates.	High, especially near the impeller blades. Can be detrimental to fragile cells, although impeller designs have been optimized to reduce this.
Scalability	Linear. The hydrodynamic conditions remain consistent as the volume increases, allowing for predictable scale-up.	Complex. Scaling up requires careful optimization to maintain consistent conditions, as fluid dynamics change with volume.
Homogeneity	Excellent. The vertical wheel creates a highly uniform environment with eliminating occurrences of high turbulence.	Good. Requires careful design to ensure uniform mixing and prevent gradients, especially in large vessels.
Applications	Primary: Shear-sensitive cell cultures (hiPSCs, MSCs, T-cells), viral vectors, and exosomes	Primary: Large-scale fermentation (bacteria, yeast), and general mammalian cell culture (e.g., CHO cells for biologics).

Product Parts and Technical Specifications

Product Type	Product	Product Number
Base Unit	PBS-Mini Vertical-Wheel Bioreactor Base Unit (120-240 V)	FA-UNI-B-501	Request a quote
Single-Use Vessels	PBS-0.5 Vertical-Wheel Single-Use Vessel with Bottom Port (pack of 1)	FA-0.5-D-101	Request a quote
	PBS-0.5 Vertical-Wheel Single-Use Vessel (pack of 4)	FA-0.5-D-001	Request a quote
	PBS 0.5 Single-Use Vessel with 60μm PSC Perfusion Filter (pack of 1)	IA-0.5-D-201	Request a quote
Accessories	PBS-Mini Extended 4-Gang DC Power Distribution Cable	IA-UNI-BA-112	Request a quote

Working volume range:	100 - 300 mL (For liquid mixing) 300 - 500 mL (For cell culture)
Number of ports	2
Gassing	Diffusion through 0.22 micron filter on vent cap
Liquid transfer	Port with screw-on vent cap
Product contact materials	Meet requirements for USP Class VI Testing for Plastics and/or ISO 10993

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The PBS Mini Bioreactor 90 Day Guarantee

If you are not satisfied with the performance of the PBS-Mini products or accessories get your money back. Must show necessary performance documentation to qualify.