Articles

2022 Neto et al.
Characterization of the Aeration and Hydrodynamics in Vertical-Wheel Bioreactors
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC)
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2022 Lee et al.
Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufactruing of Allogeneic Pluripotent Stem Cell Products
Topics: induced pluripotent stem cell (iPSC); embryonic stem cell (ESC); mesenchymal stem / stromal cell (MSC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
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2022 Croughan et al.
Initial Power Measurements for a Family of Novel Vertical-Wheel Bioreactors
Topics: power number; Reynolds number
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2021 Silva et al.
Transcriptome Profiling of Human Pluripotent Stem Cell‐Derived Cerebellar Organoids Reveals Faster Commitment Under Dynamic Conditions.pdf
Keywords: induced pluripotent stem cell (iPSC); organoid; expansion; differentiation
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2021 Dang et al.
Computational Fluid Dynamic Characterization of Vertical-Wheel Bioreactors Used for Effective Scale-up of Human Induced Pluripotent Stem Cell Aggregate Culturess
Keywords: induced pluripotent stem cell (iPSC); aggregates; computational fluid dynamics (CFD)
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2021 Borys et al.
Overcoming Bioprocess Bottlenecks in the Large-Scale Expansion of High-Quality hiPSC Aggregates in Vertical-Wheel Stirred Suspension Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregates; expansion; scalable manufacturing
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2020 Silva et al.
Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining
Keywords: induced pluripotent stem cell (iPSC); aggregate; organoid; expansion; differentiation
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2020 Lembong et al.
Bioreactor Parameters for Microcarrier-Based Human MSC Expansion Under Xeno-Free Conditions in a Vertical-Wheel System
Keywords: mesenchymal stem / stromal cell (MSC); microcarrier
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2020 Lee et al.
Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
Topics: induced pluripotent stem cell (iPSC); embryonic stem cell (ESC); mesenchymal stem / stromal cell (MSC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
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2020 Borys et al.
Optimized Serial Expansion of Human Induced Pluripotent Stem Cells Using Low-Density Inoculation to Generate Clinically Relevant Quantities in Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregate; serial expansion
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2019 Nogueria et al.
Strategies for the Expansion of hiPSCs as Aggregates in Single-Use Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (IPSC); aggregates; expansion
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2018 Rodrigues et al.
Scalable Culture of Human Induced Pluripotent Cells on Microcarriers Under Xeno-Free conditions Using Single-Use Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); microcarriers; expansion
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2018 Rodrigues et al.
Scalable Culture Of Human Induced Pluripotent Stem Cells On Microcarriers Under Xeno-Free Conditions
Topics: induced pluripotent stem cell (iPSC); microcarrier
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2018 Jung et al.
Quality Manufacturing of Mesenchymal Stem/Stromal Cells Using Scalable and Controllable Bioreactor Platforms
Keywords: mesenchymal stem / stromal cell (MSC); microcarriers; scalable manufacturing
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Presentations

2022 ECI conference
Challenges and Solutions for Allogeneic Cell Therapy Manufacturing
Keywords: induced pluripotent stem cell (iPSC); mesenchymal stem / stromal cell (MSC); aggregate; microcarrier; computational fluid dynamics (CFD); hydrodynamics; scalable manufacturing
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2022 ARM Meeting on the Mesa conference
Enabling The Commercialization Of Allogeneic Cell Therapy Products
Keywords: commercialization; scalable manufacturing; induced pluripotent stem cell (iPSC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
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2020 RegMedNet webinar
Scalable Manufacturing of Allogeneic Cell Therapy Products Using Vertical-Wheel Bioreactors
Topics: induced pluripotent stem cell (iPSC); human embryonic stem cell (ESC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
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2020 Phacilitate conference
Optimizing Human Induced Pluripotent Stem Cell (hiPSC) Production Process Using Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregate; serial passage; harvest
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Posters

2022 ECI conference
Protocol Development to Overcome Bioprocess Bottlenecks in the Large-Scale Expansion of High Quality hiPSC Aggregates in Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregate; expansion; protocol
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2022 ECI conference
Computational Fluid Dynamic Characterization of Vertical-Wheel Bioreactors For Effective Scale-Up of Human Induced Pluripotent Stem Cell Aggregate Culture
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC); aggregate
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2022 ECI conference
Challenges and Solutions for Allogeneic Cell Therapy Manufacturing
Keywords: induced pluripotent stem cell (iPSC); aggregates; process development; protocol; scalable manufacturing
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2021 ISSCR conference
Scalable Manufacturing Of Human Mesenchymal Stem/Stromal Cells And Induced Pluripotent Stem Cells In Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); mesenchymal stem / stromal cell (MSC); scalable manufacturing; computational fluid dynamics (CFD); hydrodynamics
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2021 ISCT conference
Effective Scale-Up of Human Induced Pluripotent Stem Cell Aggregate Culture in Vertical-Wheel Bioreactors through Computational Fluid Hydrodynamic Characterization
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC); aggregate
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2019 iBB conference
Induced Pluripotent Cell Culture Using Single-Use Vertical-Wheel Bioreactors Under Xeno-Free Conditions
Keywords: induced pluripotent stem cell (iPSC); microcarrier; pluripotency
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2019 ECI conference
Computational Fluid Dynamics Modeling of Single-Use, Verical-Wheel Bioreactors as a Predictive Scale-up Tool for Large Scale Stem Cell Culture
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC); aggregate
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2019 ECI conference
Engineering Characterization of a Versatile Vertical-Wheel Bioreactor for Cell and Gene Therapy
Keywords: power number; Reynolds number; microcarrier
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