Publications
2024 Iworma et al.
Metabolic Switching, Growth Kinetics and Cell Yields in the Scalable Manufacture of Stem Cell‑Derived Insulin‑Producing Cells
Topics: bioprocess development; type 1 diabetes (T1D); islet beta cell; pluripotent stem cell (PSC); differentiation
2023 Vallabhaneni et al.
Suspension Culture on Microcarriers and as Aggregates Enables Expansion and Differentiation of Pluripotent Stem Cells
Topics: induced pluripotent stem cell (iPSC); aggregates; microcarrier; expansion; differentiation; CBER; FDA
2023 Roberts et al.
Computer Controlled Expansion of Equine Cord Blood MSCs on Microcarriers in 3L Vertical-Wheel Bioreactors
Keywords: equine cord blood; mesenchymal stromal cell (MSC); microcarriers; PBS-3; Vertical-Wheel bioreactor; process scale up
2023 Roberts et al.
Bioprocess Development for Cord Blood Mesenchymal Stromal Cells on Microcarriers in Vertical‐Wheel Bioreactors
Keywords: equine cord blood; mesenchymal stromal cell (MSC); microcarriers; PBS-3; Vertical-Wheel bioreactor; process scale up
2023 Cuesta-Gomez et al.
Suspension Culture Improves iPSC Expansion and Pluripotency Phenotype
Topics: induced pluripotent stem cell (iPSC); aggregates; expansion; pluripotency
2022 Neto et al.
Characterization of the Aeration and Hydrodynamics in Vertical-Wheel Bioreactors
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC)
2022 Lee et al.
Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
Topics: induced pluripotent stem cell (iPSC); embryonic stem cell (ESC); mesenchymal stem / stromal cell (MSC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
2022 Croughan et al.
Initial Power Measurements for a Family of Novel Vertical-Wheel Bioreactors
Topics: power number; Reynolds number
2021 Silva et al.
Transcriptome Profiling of Human Pluripotent Stem Cell‐Derived Cerebellar Organoids Reveals Faster Commitment Under Dynamic Conditions.pdf
Keywords: induced pluripotent stem cell (iPSC); organoid; expansion; differentiation
2021 Dang et al.
Computational Fluid Dynamic Characterization of Vertical-Wheel Bioreactors Used for Effective Scale-up of Human Induced Pluripotent Stem Cell Aggregate Culture
Keywords: induced pluripotent stem cell (iPSC); aggregates; computational fluid dynamics (CFD)
2021 Borys et al.
Overcoming Bioprocess Bottlenecks in the Large-Scale Expansion of High-Quality hiPSC Aggregates in Vertical-Wheel Stirred Suspension Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregates; expansion; scalable manufacturing
2020 Silva et al.
Scalable Generation of Mature Cerebellar Organoids from Human Pluripotent Stem Cells and Characterization by Immunostaining
Keywords: induced pluripotent stem cell (iPSC); aggregate; organoid; expansion; differentiation
2020 Lembong et al.
Bioreactor Parameters for Microcarrier-Based Human MSC Expansion Under Xeno-Free Conditions in a Vertical-Wheel System
Keywords: mesenchymal stem / stromal cell (MSC); microcarrier
2020 Lee et al.
Challenges and Solutions for Commercial Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products
Topics: induced pluripotent stem cell (iPSC); embryonic stem cell (ESC); mesenchymal stem / stromal cell (MSC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
2020 Borys et al.
Optimized Serial Expansion of Human Induced Pluripotent Stem Cells Using Low-Density Inoculation to Generate Clinically Relevant Quantities in Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregate; serial expansion
2019 Nogueria et al.
Strategies for the Expansion of hiPSCs as Aggregates in Single-Use Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (IPSC); aggregates; expansion
2018 Rodrigues et al.
Scalable Culture of Human Induced Pluripotent Cells on Microcarriers Under Xeno-Free conditions Using Single-Use Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); microcarriers; expansion
2018 Rodrigues et al.
Scalable Culture Of Human Induced Pluripotent Stem Cells On Microcarriers Under Xeno-Free Conditions
Topics: induced pluripotent stem cell (iPSC); microcarrier
2018 Jung et al.
Quality Manufacturing of Mesenchymal Stem/Stromal Cells Using Scalable and Controllable Bioreactor Platforms
Keywords: mesenchymal stem / stromal cell (MSC); microcarriers; scalable manufacturing
Presentations
2022 ECI conference
Challenges and Solutions for Allogeneic Cell Therapy Manufacturing
Keywords: induced pluripotent stem cell (iPSC); mesenchymal stem / stromal cell (MSC); aggregate; microcarrier; computational fluid dynamics (CFD); hydrodynamics; scalable manufacturing
2022 ARM Meeting on the Mesa conference
Enabling The Commercialization Of Allogeneic Cell Therapy Products
Keywords: commercialization; scalable manufacturing; induced pluripotent stem cell (iPSC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
2020 RegMedNet webinar
Scalable Manufacturing of Allogeneic Cell Therapy Products Using Vertical-Wheel Bioreactors
Topics: induced pluripotent stem cell (iPSC); human embryonic stem cell (ESC); aggregate; expansion; differentiation; computational fluid dynamics (CFD); hydrodynamics
Posters
2023 Taberna et al.
Producing T Cell Competent Blood Progenitor Cells From Pluripotent Stem Cells in Scalable Dynamic Suspension Culture
Keywords: T cell; pluripotent stem cell (PSC); expansion; differentiation
2023 ECI Conference
Novel Vertical-Wheel Bioreactors for the Scalable, Robust and Efficient Production of Shear Sensitive Cell Therapy Products
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC); aggregate; mesenchymal stromal cell (MSC)
2022 ECI conference
Protocol Development to Overcome Bioprocess Bottlenecks in the Large-Scale Expansion of High Quality hiPSC Aggregates in Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); aggregate; expansion
2022 ECI conference
Computational Fluid Dynamic Characterization of Vertical-Wheel Bioreactors For Effective Scale-Up of Human Induced Pluripotent Stem Cell Aggregate Culture
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC); aggregate
2022 ECI conference
Challenges and Solutions for Allogeneic Cell Therapy Manufacturing
Keywords: induced pluripotent stem cell (iPSC); aggregates; process development; protocol; scalable manufacturing
2021 ISSCR conference
Scalable Manufacturing Of Human Mesenchymal Stem/Stromal Cells And Induced Pluripotent Stem Cells In Vertical-Wheel Bioreactors
Keywords: induced pluripotent stem cell (iPSC); mesenchymal stem / stromal cell (MSC); scalable manufacturing; computational fluid dynamics (CFD); hydrodynamics
2021 ISCT conference
Effective Scale-Up of Human Induced Pluripotent Stem Cell Aggregate Culture in Vertical-Wheel Bioreactors through Computational Fluid Hydrodynamic Characterization
Keywords: computational fluid dynamics (CFD); hydrodynamics; induced pluripotent stem cell (iPSC); aggregate