Designed for Cell Therapy Processes
The Vertical-Wheel® bioreactor family provides robust, scalable, and flexible performance for any stage of cell manufacturing.
Single-Use Systems for All Your Scale Up Needs
From small scale process development to large scale clinical and commercial production, Vertical-Wheel bioreactors are the enabling technology for allogeneic cell therapies. All bioreactors, including product contact materials and software, are manufactured to meet or exceed cGMP quality and regulatory standards.
PBS-0.1 Mini Vertical-Wheel Bioreactor
The entry-level tool for representative process development 0.1 L maximum working volumes available.
PBS-0.5 Mini Vertical-Wheel Bioreactor
The entry-level tool for representative process development 0.5 L maximum working volumes available.
PBS-3 Vertical-Wheel Bioreactor
Take your process development to the next level with this full feature bioreactor. 3L maximum working volume.
PBS-15 Vertical-Wheel Bioreactor
Continue your cell culture process scale up for clinical stage production. 15L maximum working volume.
PBS-80 Vertical-Wheel Bioreactor
Prepare for commercial-scale manufacturing of your cell therapy products. 80L maximum working volume.
Vertical-Wheel Bioreactor Components
Electromechanical Housing Features
- Stainless steel construction with minimal footprint
- Simple connection of gas lines and mass flow controllers for gas intake and filtered output
- Integrated touchscreen user interface for customizable process control
- Adjustable height harvest valve for rapid harvest or medium exchange (PBS-15 and PBS-80 only)
- Safety interlocks for emergency process stop, fluid spill catch, and remote alerts
Single-Use Vessel Features
- Injection-molded plastics: polycarbonate (Vertical-Wheel impellers, vessels for PBS Minis and PBS-3) or PVDF (vessels for PBS-15 and PBS-80)
- Product contact materials meet or exceed requirements for USP Class VI Testing for
Plastics <88> and/or ISO 10993 - Embedded magnets allow for coupled rotation of impeller with no axle penetration
- Sterile access ports for single-use or reusable sensors, sampling, and harvesting tubes
Proprietary Software Features
- Simple and customizable programming for control of cell culture process parameters
- Autopilot feature controls pumps based on real-time feedback from sensors
- Can be used to meet 21 CFR Part 11 cGMP requirements for security and history of user access
- Recorded audit trail and process data backup to local or network drive
- Options for wireless process control and alarm reporting
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