Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical-Wheel bioreactors
Introduction
Advanced protocols show potential for human stem cells (SC)-derived islets generation under planar (2D) alone or three-dimensional (3D) cultures, but show challenges in scalability, cell loss, and batch to- batch consistency. This study explores Vertical Wheel (VW)® bioreactor suspension technology to differentiate islets from human induced pluripotent stem cells,
