Designed for Cell Therapy Processes
PBS-Mini Vertical-Wheel Bioreactor
Small-scale single-use bioreactor enables early process development using Vertical-Wheel technology. PBS-Mini base is compatible with 0.1L and 0.5L single use vessels.
PBS-0.5 Mini Perfusion Single-Use Vessel
Compact, scalable vessel designed for optimization of PSC culture under controlled perfusion medium exchange.
PBS-3 Vertical-Wheel Bioreactor
Mid-scale single-use bioreactor enables bench-scale stem cell therapy process development using Vertical-Wheel technology with bioprocess control and monitoring capabilities. 1.8 to 3L working volumes.
PBS-15 Vertical-Wheel Bioreactor
Large-scale single-use bioreactor enables clinical and commercial manufacturing-scale stem cell therapy production using Vertical-Wheel technology. 10-15L working volume.
PBS-80 Vertical-Wheel Bioreactor
Large-scale single-use bioreactor enables commercial manufacturing-scale stem cell therapy production using Vertical-Wheel technology. 50-80L working volume.
Vertical-Wheel Bioreactor Components
Electromechanical Housing Features
- Stainless steel construction with minimal footprint
- Simple connection of gas lines and mass flow controllers for gas intake and filtered output
- Integrated touchscreen user interface for customizable process control
- Adjustable height harvest valve for rapid harvest or medium exchange (PBS-15 and PBS-80 only)
- Safety interlocks for emergency process stop, fluid spill catch, and remote alerts
Single-Use Vessel Features
- Injection-molded plastics: polycarbonate (Vertical-Wheel impellers, vessels for PBS Minis and PBS-3) or PVDF (vessels for PBS-15 and PBS-80)
- Product contact materials meet or exceed requirements for USP Class VI Testing for
Plastics <88> and/or ISO 10993 - Embedded magnets allow for coupled rotation of impeller with no axle penetration
- Sterile access ports for single-use or reusable sensors, sampling, and harvesting tubes
Proprietary Software Features
- Simple and customizable programming for control of cell culture process parameters
- Autopilot feature controls pumps based on real-time feedback from sensors
- Can be used to meet 21 CFR Part 11 cGMP requirements for security and history of user access
- Recorded audit trail and process data backup to local or network drive
- Options for wireless process control and alarm reporting
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