Superior Microcarrier-Based iPSC Expansion
Introduction
Induced pluripotent stem cells (iPSCs) are used for a variety of cellular applications including toxicity studies, drug screening, disease modeling, and regenerative medicine. Although the number of cells required for each application might differ, an efficient expansion phase that reliably generates a large number of high- quality cells in a defined time period is a prerequisite for all of them. The most common method for the expansion of iPSCs is adherent culture on plastic-ware coated with commercially available matrices such as MatrigelTM, GeltrexTM, vitronectin, and laminins, or synthetic matrices such as SynthemaxTM
