PBS Biotech Exhibits at ESACT, Selected to Present Technical Poster to Entire Global Group of Scientists
Poster highlighting novel mixing mechanism and characterization using the PBS single-use bioreactor Air-Wheel™ system wins accolades from ESACT judges
Camarillo, California, May 31, 2011–PBS Biotech, Inc., a developer of state of the art single-use bioreactors used in the fast growing biotechnology market, announced today its technical poster was selected for presentation before the entire 22nd Annual European Society for Animal Cell Technology (ESACT) conference in Vienna, Austria, May 15 – 18. The conference, which brings together leading biotech and pharmaceutical scientists from companies, academic institutions and research centers from around the world to share scientific gains and equipment, is the premier biotech exhibition in Europe.
The poster, a winner in its category, outlines the scientific experiments the company has conducted recently using the Air-Wheel™ mixing technology in its single-use bioreactors with world leading academic institutions and biotech firms demonstrating rapid mixing, low shear and high cell density growth. The poster is entitled: “Characterization of Novel Pneumatic Mixing for Single-Use Bioreactor Application” and can be downloaded from the PBS Biotech web site by clicking here.
On the final day of ESACT, Dr. Brian Lee, PBS Biotech president and co-founder, presented the poster abstract and results before the full ESACT attendee list of nearly 1,000 world-renown scientists and researchers.
In its abstract PBS Biotech team and its collaboration partners outlined the company’s novel bioreactor system which incorporates the patented Air-Wheel technology, promotes uniform and homogeneous mixing and offers low shear environment for cell culture, as evidenced by mixing tests and computational fluid dynamics (CFD) modeling performed over a wide range of working volumes.
The poster was developed based on recent biological tests conducted with Keck Graduate Institute, Claremont, CA; Instituto de Biologia Experimental e Tecnologico (IBET), Lisbon, Portugal, and Green Cross Corporation, Korea. These tests and production runs have shown scalable growth performance for a high cell density process in 3 liter and 15 liter PBS systems and comparable growth and product performance in the 250 liter PBS system against a 300 liter stirred tank system using an Fc-fusion protein-producing process. The poster was jointly created with Dr. Matthew Croughan at KGI, Dr. Manual Carrondo of IBET Portugal, and Sang-Hoon Paik, of Green Cross Central Research Center, Seoul.
PBS bioreactor systems are the first with a pneumatic mixing device powered solely by gas buoyancy, eliminating the need for an external mechanical agitator. The patented design of the Air-Wheel mixing device promotes not only high tangential fluid flow around the wheel but also efficient radial and axial flow. The leverage effect of the Air- Wheel mixing device allows lower gassing requirement (v/v) with increasing working volume.
At ESACT the company exhibited its product line of next generation single-use bioreactors for use in developing cell cultures for wide range of products including mAbs, proteins, vaccines, viruses, stem cells and personalized medicine. The company displayed its PBS 3, PBS 15 and PBS 80 liter bioreactors used in batch, fed batch, perfusion and transient transfection processes and use with micro-carriers and many other cell culture apps.
The company projects rapid adoption of single-use bioreactors across all stages of the bioprocess as firms desire to embrace single-use technology in general and a biotech industry desiring to drive out costs in both R&D and production while increasing process flexibility, operational efficiency and accelerating time to market.
The PBS Biotech line of products are most advanced in the industry featuring ease of use, full scalability from lab to production, low shear from the novel Air-Wheel™ mixing mechanism and plug and play configurations.
About PBS Biotech
PBS Biotech, Inc. is a US corporation that designs and manufactures fully scalable and easy to use single-use bioreactors used by global biotechnology organizations. The company has patented innovative industrial designs and advanced software driven control systems that produce low shear cell culture solutions improving operational flexibility and process efficiency, reducing operating costs and accelerating time to market for biotechnology customers. With headquarters in Camarillo, CA., PBS Biotech is a member of the BioProcess Systems Alliance (BPSA).
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